Is there a “Best Way” to build a site?
When designing a new site one of the questions asked most often is “Do I design my site for human visitors or the search engines?”
I have always believed that if you build your site for the human visitor first the search engines will find you and reward you. There may be some things that you can do for the search engines specifically that probably won’t noticed by your visitors.
Here’s a good discussion at Highrankings.com on the topic.